Tadalafil Effect Duration And Side Effects
Tadalafil effect duration
The effects of tadalafil begin to manifest themselves after 16–30 min (with erectile dysfunction), approximately four weeks (improvement walking distance in pulmonary hypertension). Duration of action of tadalafil is 36 hours (with erectile dysfunction), which makes it the longest-acting erectile dysfunction drug in the history of oral impotence treatments. In the table below, we are presenting the pharmacodynamic characteristics of tadalafil:
| Pharmacodynamic Data | Tadalafil Citrate |
|---|---|
| Absorption | Quick. Food has no effect on absorption. |
| T max | 2–4 hours |
| Protein binding | 94% |
| V d | Approx.1 l / kg. |
| Metabolism | Mainly by CYP3A4 to low active metabolites |
| Elimination | Mainly as inactive metabolites with the faeces (61%), with the urine (36%). Tadalafil is not removed by hemodialysis. |
| T 1/2 | Approx. 17 hours |
| T 1 / 2el | Approx. 36 hours |
Tadalafil side effects
Side effects of tadalafil are, as a general rule, well-tolerated and mild. You need to talk to your doctor about changing the dose if they become persistent or intense. However, studies have shown that the extended use of tadalafil helps your body to adjust to its effects and side effects, which leads to better response and tolerance rates (source: Long-Term Safety And Tolerability Of Tadalafil In The Treatment Of Erectile Dysfunction).
Frequency Of Tadalafil Side Effects | Adverse Reaction Symptoms
Common side effects of tadalafil (1-10%): Headache, syncope, flushing, nasal congestion, Dyspepsia, Muscle pain, back pain, pain in the extremities.
How to minimize and avoid tadalafil side effects
Tadalafil side effects can be easily mitigated or even prevented if you take the drug after a meal. Luckily, the substance’s beneficial effects are not altered when you take it with a heavy meal – this is another advantage of tadalafil molecule.
Avoid the use of tadalafil with alcohol at all times if you would like to avoid the side effects related to low blood pressure (headache, nausea, fainting) and other drugs if you have not discussed their combined use with tadalafil with your doctor.